Best way to locate part on table?

Basically what I am trying to acomplish is making wheels for an RC car. Starting with 2.5" delrin rod. What would you suggest to fixture these one at a time in the same exact place every time, also how would you zero your machine in the x and y axis.

I would make a jig to hold the wheel and use the center of the wheel as my zero point.

Set home position to center of artwork

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Made a quick 3 point jig tonight that seems to work well. Thank you for the link to that thread, I too thought that if the artwork was outside the art board that it wouldn’t be cut. I will expire meant with it more tomorrow evening.