Well, did you define the work zero in that location?
You could still carve it using that file by simply jogging back on the Y-Axis and right on the X-Axis far enough such that all of the work would be carved on the area desired, set the work home in Easel, and then just carve away. The machine will be carving in negative X and Y, but it does not care as long as you set Easel’s work zero far enough to the back and right to compensate for the work being in the third quadrant.
Doing that would be no different than the way a lot of people carve circular objects. Find the center of the physical circular work piece, set the work zero to that location, move the object (designed in Easel) to have a (0,0) center position, and carve away.