You cabinet and workshop looks very fine!
However, do nor forget to have a system with a vacuum cleaner (or bigger) to remove all the milling chips and dust, because there will be a LOT…
Regarding the placement I usually have the zero point in the lower left corner and the placing the milling piece some mm up and right. Just look so you have enough of material. I have experienced some problems with my internet connection as I use easel. If you lose the connection for jst a fraction of a second everything id ruined. Ensure a good internet connection and a good USB cable as well.